Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs

Table 1 Mutated viral strain analysis. Percentages of viral strain carrying the rtM204V/I or the rtN236T mutation determined with in-house selective real-time PCR (ARMS).

Date	Treatment	HBV viral load (log IU/mL)	% rtM204 (wt)	% rtM204V	% rtM204I	% rtN236 (wt)	% rtN236T
M0	LMV	8.6	100	0	0	-	-
M3	LMV	5.2	100	0	0	-	-
M7	LMV	6.1	28	48	24	-	-
M10	LMV	8.1	34	45	21	-	-
M12	LMV	8.6	22	58	20	-	-
M14	LMV	8.8	30	50	20	-	-
M16	LMV + ADV	5.9	8	67	25	-	-
M19	LMV + ADV	5.2	37	43	20	-	-
M22	LMV + ADV	4.8	24	51	25	-	-
M24	LMV + ADV	4.6	26	49	25	-	-
M27	LMV + ADV	4.1	66	19	15	-	-
M30	LMV + ADV	4.2	66	22	12	-	-
M36	ADV	3.3	83	7	10	100	0
M39	ADV	3.3	74	8	18	100	0
M42	ADV	2.6	75	8	17	96	4
M46	ADV	3.4	82	8	10	79	21
M48	ADV	4.1	98	2	0	66	34
M51	LMV + ADV	3.0	87	0	13	71	29
M55	LMV + ADV	2.9	86	14	0	73	27